References

Abraham M, Alramadhan S, Iniguez C A systematic review of maternal smoking during pregnancy and fetal measurements with meta-analysis. PLoS One.. 2017; 12:(2) https://doi.org/10.1371/journal.pone.0170946

Adams TNMJ Smoking. 2022;

Addis A, Moretti ME, Ahmed Syed F, Einarson TR, Koren G Fetal effects of cocaine: an updated meta-analysis. Reprod Toxicol.. 2001; 15:(4)341-369 https://doi.org/10.1016/S0890-6238(01)00136-8

Anderson K, Nisenblat V, Norman R Lifestyle factors in people seeking infertility treatment - a review. Aust N Z J Obstet Gynaecol.. 2010; 50:(1)8-20 https://doi.org/10.1111/j.1479-828X.2009.01119.x

Angelo FN, Miller HE, Zoellner LA, Feeny NC “I need to talk about it”: a qualitative analysis of trauma-exposed women's reasons for treatment choice. Behav Ther.. 2008; 39:(1)13-21 https://doi.org/10.1016/j.beth.2007.02.002

Battista N, Pasquariello N, Di Tommaso M, Maccarrone M Interplay between endocannabinoids, steroids and cytokines in the control of human reproduction. J Neuroendocrinol. 2008; 20:(s1)82-89 https://doi.org/10.1111/j.1365-2826.2008.01684.x

Baía I, Domingues RMSM The effects of cannabis use during pregnancy on low birth weight and preterm birth: a systematic review and meta-analysis. Am J Perinatol.. 2022; https://doi.org/10.1055/a-1911-3326

Braga DPAF, Halpern G, Setti AS, Figueira RCS, Iaconelli A, Borges E The impact of food intake and social habits on embryo quality and the likelihood of blastocyst formation. Reprod Biomed Online.. 2015; 31:(1)30-38 https://doi.org/10.1016/j.rbmo.2015.03.007

Brecht ML, Herbeck DM Pregnancy and fetal loss reported by methamphetamine-using women. Subst Abuse.. 2014; 8 https://doi.org/10.4137/SART.S14125

Budani MC, Tiboni GM Ovotoxicity of cigarette smoke: a systematic review of the literature. Reprod Toxicol.. 2017; 72:164-181 https://doi.org/10.1016/j.reprotox.2017.06.184

Bull FC, Al-Ansari SS, Biddle S World Health Organization 2020 guidelines on physical activity and sedentary behaviour. Br J Sports Med.. 2020; 54:(24)1451-1462 https://doi.org/10.1136/bjsports-2020-102955

Cao H, Ren J, Feng X, Yang G, Liu J Is caffeine intake a risk factor leading to infertility? A protocol of an epidemiological systematic review of controlled clinical studies. Syst Rev.. 2016; 5 https://doi.org/10.1186/s13643-016-0221-9

Chan CHY, Chan CLW, Ng SM, Ng EHY, Ho PC Body-mind-spirit intervention for IVF Women. J Assist Reprod Genet.. 2005; 22:(11-12)419-427 https://doi.org/10.1007/s10815-005-6418-9

Chandravati MM, Tripathi P Prediction and treatment of risk factors affecting invitro fertilization therapy. Ann Med Health Sci Res.. 2021; 11:(7)1546-1551

Chen Z, Boreham J Smoking and cardiovascular disease. Semin Vasc Med.. 2002; 02:(3)243-252 https://doi.org/10.1055/s-2002-35392

Churchill R, Teo K, Kervin L, Riadi I, Cosco TD Exercise interventions for stress reduction in older adult populations: a systematic review of randomized controlled trials. Health Psychol Behav Med.. 2022; 10:(1)913-934 https://doi.org/10.1080/21642850.2022.2125874

Cressman AM, Natekar A, Kim E, Koren G, Bozzo P Cocaine abuse during pregnancy. J Obstet Gynaecol Can.. 2014; 36:(7)628-631 https://doi.org/10.1016/S1701-2163(15)30543-0

Deepak Kumar K, Huntriss R, Green E, Bora S, Pettitt C Development of a nutrition screening tool to identify need for dietetic intervention in female infertility. J Hum Nutr Diet.. 2023; 36:(1)154-168 https://doi.org/10.1111/jhn.13055

De Wert G, Dondorp W, Shenfield F ESHRE task force on ethics and law 23: medically assisted reproduction in singles, lesbian and gay couples, and transsexual people. Hum Reprod.. 2014; 29:(9)1859-1865 https://doi.org/10.1093/humrep/deu183

Emokpae MA, Brown SI Effects of lifestyle factors on fertility: practical recommendations for modification. Reprod Fertil.. 2021; 2:(1)R13-R26 https://doi.org/10.1530/RAF-20-0046

Fell M, Dack K, Chummun S, Sandy J, Wren Y, Lewis S Maternal cigarette smoking and cleft lip and palate: a systematic review and meta-analysis. Cleft Palate Craniofac J.. 2022; 59:(9)1185-1200 https://doi.org/10.1177/10556656211040015

Firns S, Cruzat VF, Keane KN The effect of cigarette smoking, alcohol consumption and fruit and vegetable consumption on IVF outcomes: a review and presentation of original data. Reprod Biol Endocrinol.. 2015; 13:(1) https://doi.org/10.1186/s12958-015-0133-x

Foeller ME, Lyell DJ Marijuana use in pregnancy: concerns in an evolving era. J Midwifery Womens Health.. 2017; 62:(3)363-367 https://doi.org/10.1111/jmwh.12631

Forray A Substance use during pregnancy. F1000 Res.. 2016; 5 https://doi.org/10.12688/f1000research.7645.1

Gaskins AJ, Nassan FL, Chiu YH Dietary patterns and outcomes of assisted reproduction. Am J Obstet Gynecol.. 2019; 220:(6)e1-e18 https://doi.org/10.1016/j.ajog.2019.02.004

Gaskins AJ, Rich-Edwards JW, Williams PL, Toth TL, Missmer SA, Chavarro JE Pre-pregnancy caffeine and caffeinated beverage intake and risk of spontaneous abortion. Eur J Nutr.. 2018; 57:(1)107-117 https://doi.org/10.1007/s00394-016-1301-2

Gormack AA, Peek JC, Derraik JGB, Gluckman PD, Young NL, Cutfield WS Many women undergoing fertility treatment make poor lifestyle choices that may affect treatment outcome. Hum Reprod.. 2015; 30:(7)1617-1624 https://doi.org/10.1093/humrep/dev094

Gouin K, Murphy K, Shah PS Knowledge synthesis group on determinants of low birth weight and preterm births. effects of cocaine use during pregnancy on low birthweight and preterm birth: systematic review and metaanalyses. Am J Obstet Gynecol.. 2011; 204:(4) https://doi.org/10.1016/j.ajog.2010.11.013

Hackshaw A, Rodeck C, Boniface S Maternal smoking in pregnancy and birth defects: a systematic review based on 173 687 malformed cases and 11.7 million controls. Hum Reprod Update.. 2011; 17:(5)589-604 https://doi.org/10.1093/humupd/dmr022

Hamer M, Taylor A, Steptoe A The effect of acute aerobic exercise on stress related blood pressure responses: a systematic review and meta-analysis. Biol Psychol.. 2006; 71:(2)183-190 https://doi.org/10.1016/j.biopsycho.2005.04.004

Har-Gil E, Heled A, Dixon M, Ahamed AMS, Bentov Y The relationship between cannabis use and IVF outcome—a cohort study. J Cannabis Res.. 2021; 3:(1) https://doi.org/10.1186/s42238-021-00099-5

Hayatbakhsh MR, Flenady VJ, Gibbons KS Birth outcomes associated with cannabis use before and during pregnancy. Pediatr Res.. 2012; 71:(2)215-219 https://doi.org/10.1038/pr.2011.25

Hernáez Á, Wootton RE, Page CM Smoking and infertility: multivariable regression and Mendelian randomization analyses in the Norwegian mother, father and child cohort study. Fertil Steril.. 2022; 118:(1)180-190 https://doi.org/10.1016/j.fertnstert.2022.04.001

Hill B, Incollingo Rodriguez AC Weight stigma across the preconception, pregnancy, and postpartum periods: a narrative review and conceptual model. Semin Reprod Med.. 2020; 38:(06)414-422 https://doi.org/10.1055/s-0041-1723775

Homan G, Litt J, Norman RJ The FAST study: fertility assessment and advice targeting lifestyle choices and behaviours: a pilot study. Hum Reprod.. 2012; 27:(8)2396-2404 https://doi.org/10.1093/humrep/des176

Hornstein MD Lifestyle and IVF outcomes. Reprod Sci.. 2016; 23:(12)1626-1629 https://doi.org/10.1177/1933719116667226

Hulse GK, Milne E, English DR, Holman CDJ Assessing the relationship between maternal opiate use and neonatal mortality. Addiction.. 1998; 93:(7)1033-1042 https://doi.org/10.1046/j.1360-0443.1998.93710338.x

Karayiannis D, Kontogianni MD, Mendorou C, Douka L, Mastrominas M, Yiannakouris N Association between adherence to the Mediterranean diet and semen quality parameters in male partners of couples attempting fertility. Hum Reprod.. 2017; 32:(1)215-222 https://doi.org/10.1093/humrep/dew288

Kellow NJ, Le Cerf J, Horta F, Dordevic AL, Bennett CJ The effect of dietary patterns on clinical pregnancy and live birth outcomes in men and women receiving assisted reproductive technologies: a systematic review and meta-analysis. Adv Nutr.. 2022; 13:(3)857-874 https://doi.org/10.1093/advances/nmac023

Kermack AJ, Calder PC, Houghton FD, Godfrey KM, Macklon NS A randomised controlled trial of a preconceptional dietary intervention in women undergoing IVF treatment (PREPARE trial). BMC Womens Health.. 2014; 14:(1) https://doi.org/10.1186/1472-6874-14-130

Klonoff-Cohen H, Natarajan L, Marrs R, Yee B Effects of female and male smoking on success rates of IVF and gamete intra-Fallopian transfer. Hum Reprod.. 2001; 16:(7)1382-1390 https://doi.org/10.1093/humrep/16.7.1382

Klonoff-Cohen HS, Natarajan L, Victoria Chen R A prospective study of the effects of female and male marijuana use on in vitro fertilization (IVF) and gamete intrafallopian transfer (GIFT) outcomes. Am J Obstet Gynecol.. 2006; 194:(2)369-376 https://doi.org/10.1016/j.ajog.2005.08.020

Klonoff-Cohen HS, Natarajan L The effect of advancing paternal age on pregnancy and live birth rates in couples undergoing in vitro fertilization or gamete intrafallopian transfer. Am J Obstet Gynecol.. 2004; 191:(2)507-514 https://doi.org/10.1016/j.ajog.2004.01.035

Kondo T, Nakano Y, Adachi S, Murohara T Effects of tobacco smoking on cardiovascular disease. Circ J.. 2019; 83:(10)1980-1985 https://doi.org/10.1253/circj.CJ-19-0323

Koning A, Mol BW, Dondorp W It is not justified to reject fertility treatment based on obesity. Hum Reprod Open.. 2017; 2017:(2) https://doi.org/10.1093/hropen/hox009

Lyngsø J, Ramlau-Hansen CH, Bay B, Ingerslev HJ, Hulman A, Kesmodel US Association between coffee or caffeine consumption and fecundity and fertility: a systematic review and dose—response meta-analysis. Clin Epidemiol.. 2017; 9:699-719 https://doi.org/10.2147/CLEP.S146496

Läänelaid S, Ortega FB, Kunovac Kallak T Physical and sedentary activities in association with reproductive outcomes among couples seeking infertility treatment: a prospective cohort study. Int J Environ Res Public Health.. 2021; 18:(5) https://doi.org/10.3390/ijerph18052718

Mbah AK, Alio AP, Fombo DW, Bruder K, Dagne G, Salihu HM Association between cocaine abuse in pregnancy and placenta-associated syndromes using propensity score matching approach. Early Hum Dev.. 2012; 88:(6)333-337 https://doi.org/10.1016/j.earlhumdev.2011.09.005

Mena GP, Mielke GI, Brown WJ The effect of physical activity on reproductive health outcomes in young women: a systematic review and meta-analysis. Hum Reprod Update.. 2019; 25:(5)542-564 https://doi.org/10.1093/humupd/dmz013

Metz TD, Borgelt LM Marijuana use in pregnancy and while breastfeeding. Obstet Gynecol.. 2018; 132:(5)1198-1210 https://doi.org/10.1097/AOG.0000000000002878

Mikkelsen K, Stojanovska L, Polenakovic M, Bosevski M, Apostolopoulos V Exercise and mental health. Maturitas.. 2017; 106:48-56 https://doi.org/10.1016/j.maturitas.2017.09.003

Miko HC, Zillmann N, Ring-Dimitriou S, Dorner TE, Titze S, Bauer R Effects of physical activity on health. Gesundheitswesen. 2020; 82:(S 03)s184-s195 https://doi.org/10.1055/a-1217-0549

Miller CB, Wright T Investigating mechanisms of stillbirth in the setting of prenatal substance use. Acad Forensic Pathol.. 2018; 8:(4)865-873 https://doi.org/10.1177/1925362118821471

Mueller BA, Daling JR, Weiss NS, Moore DE Recreational drug use and the risk of primary infertility. Epidemiol.. 1990; 1:(3)195-200 https://doi.org/10.1097/00001648-199005000-00003

Muffone A, de Oliveira Lübke PDP, Rabito EI Mediterranean diet and infertility: a systematic review with meta-analysis of cohort studies. Nutr Rev.. 2022; 81:(7)775-789 https://doi.org/10.1093/nutrit/nuac087

Nassan FL, Arvizu M, Mínguez-Alarcón L Marijuana smoking and outcomes of infertility treatment with assisted reproductive technologies. Hum Reprod.. 2019; 34:(9)1818-1829 https://doi.org/10.1093/humrep/dez098

National Institute for Health and Care Excellence. Nice guideline CG62. 2008. http://www.nice.org.uk/guidance/cg62/chapter/1-recommendations#lifestyle-considerations

Newcomb PA, Carbone PP The health consequences of smoking: cancer. Med Clin North Am.. 1992; 76:(2)305-331 https://doi.org/10.1016/S0025-7125(16)30355-8

NHS. Assisted conception policy NHS: NHS Coventry and Warwickshire Clinical Commissioning Group. 2022a. https://coventrywarwickshireccg.nhs.uk/wp-content/uploads/2021/04/Assisted-Conception-Policy.pdf

NHS. Infertility and assisted conception NHS website: National Health Service - West London. 2022b. https://www.southwestlondon.icb.nhs.uk/find-nhs-services/infertility-and-assisted-conception/

Oboni JB, Marques-Vidal P, Bastardot F, Vollenweider P, Waeber G Impact of smoking on fertility and age of menopause: a population-based assessment. BMJ Open.. 2016; 6:(11) https://doi.org/10.1136/bmjopen-2016-012015

Ozbakir B, Tulay P Should fertile women quit drinking alcohol to produce better quality oocytes? Zygote. 2021; 29:(2)176-178 https://doi.org/10.1017/S0967199420000696

Park B, McPartland JM, Glass M Cannabis, cannabinoids and reproduction. Prostaglandins Leukot Essent Fatty Acids.. 2004; 70:(2)189-197 https://doi.org/10.1016/j.plefa.2003.04.007

Patten RK, Pascoe MC, Moreno-Asso A, Boyle RA, Stepto NK, Parker AG Effectiveness of exercise interventions on mental health and health-related quality of life in women with polycystic ovary syndrome: a systematic review. BMC Public Health.. 2021; 21:(1) https://doi.org/10.1186/s12889-021-12280-9

Penzias A, Bendikson K, Butts S Smoking and infertility: a committee opinion. Fertil Steril.. 2018; 110:(4)611-618 https://doi.org/10.1016/j.fertnstert.2018.06.016

Pineles BL, Park E, Samet JM Systematic review and meta-analysis of miscarriage and maternal exposure to tobacco smoke during pregnancy. Am J Epidemiol.. 2014; 179:(7)807-823 https://doi.org/10.1093/aje/kwt334

Ramlau-Hansen CH, Thulstrup AM, Nohr EA, Bonde JP, S0rensen TIA, Olsen J Subfecundity in overweight and obese couples. Hum Reprod.. 2007; 22:(6)1634-1637 https://doi.org/10.1093/humrep/dem035

Rao M, Zeng Z, Tang L Maternal physical activity before IVF/ICSI cycles improves clinical pregnancy rate and live birth rate: a systematic review and meta-analysis. Reprod Biol Endocrinol.. 2018; 16:(1) https://doi.org/10.1186/s12958-018-0328-z

Rao W, Li Y, Li N, Yao Q, Li Y The association between caffeine and alcohol consumption and IVF/ICSI outcomes: a systematic review and dose-response meta-analysis. Acta Obstet Gynecol Scand.. 2022; 101:(12)1351-1363 https://doi.org/10.1111/aogs.14464

Richardson GA, Day NL, McGauhey PJ The impact of prenatal marijuana and cocaine use on the infant and child. Clin Obstet Gynecol.. 1993; 36:(2)302-318 https://doi.org/10.1097/00003081-199306000-00010

Rittenberg V, Seshadri S, Sunkara SK, Sobaleva S, Oteng-Ntim E, El-Toukhy T Effect of body mass index on IVF treatment outcome: an updated systematic review and meta-analysis. Reprod Biomed Online.. 2011; 23:(4)421-439 https://doi.org/10.1016/j.rbmo.2011.06.018

Rockhill K, Tong VT, Boulet SL, Zhang Y, Jamieson DJ, Kissin DM Smoking and clinical outcomes of assisted reproductive technologies. J Womens Health (Larchmt).. 2019; 28:(3)314-322 https://doi.org/10.1089/jwh.2018.7293

Royal College of Obstetricians and Gynaecologists. Alcohol and Pregnancy. 2015. https://www.rcog.org.uk/en/patients/patient-leaflets/alcohol-and-pregnancy/

Ruegsegger GN, Booth FW Health benefits of exercise. Cold Spring Harb Perspect Med.. 2018; 8:(7) https://doi.org/10.1101/cshperspect.a029694

Sanderman EA, Willis SK, Wise LA Female dietary patterns and outcomes of in vitro fertilization (IVF): a systematic literature review. Nutr J.. 2022; 21:(1) https://doi.org/10.1186/s12937-021-00757-7

Santini C, Imakawa TS, Moisés ECD Erratum: physical activity during pregnancy: recommendations and assessment tools. Revista Brasileira de Ginecologia e Obstetricia.. 2017; 39:(10) https://doi.org/10.1055/s-0037-1607299

Sermondade N, Huberlant S, Bourhis-Lefebvre V a systematic review and meta-analysis. Hum Reprod Update.. 2019; 25:(4)439-451 https://doi.org/10.1093/humupd/dmz011

Sharma R, Harlev A, Agarwal A, Esteves SC Cigarette smoking and semen quality: a new meta-analysis examining the effect of the 2010 World Health Organization laboratory methods for the examination of human semen. Eur Urol.. 2016; 70:(4)635-645 https://doi.org/10.1016/j.eururo.2016.04.010

Sherwood RA, Keating J, Kavvadia V, Greenough A, Peters TJ Substance misuse in early pregnancy and relationship to fetal outcome. Eur J Pediatr.. 1999; 158:(6)488-492 https://doi.org/10.1007/s004310051126

Sneed ML, Uhler ML, Grotjan HE, Rapisarda JJ, Lederer KJ, Beltsos AN Body mass index: impact on IVF success appears age-related. Hum Reprod.. 2008; 23:(8)1835-1839 https://doi.org/10.1093/humrep/den188

Söritsa D, Mäestu E, Nuut M Maternal physical activity and sedentary behaviour before and during in vitro fertilization treatment: a longitudinal study exploring the associations with controlled ovarian stimulation and pregnancy outcomes. J Assist Reprod Genet.. 2020; 37:(8)1869-1881 https://doi.org/10.1007/s10815-020-01864-w

Thompson R, DeJong K, Lo J Marijuana use in pregnancy: a review. Obstet Gynecol Surv.. 2019; 74:(7)415-428 https://doi.org/10.1097/OGX.0000000000000685

Tremellen K, Savulescu J Posthumous conception by presumed consent. A pragmatic position for a rare but ethically challenging dilemma. Reprod Biomed Soc Online.. 2016; 3:26-29 https://doi.org/10.1016/j.rbms.2016.11.001

Tremellen K, Wilkinson D, Savulescu J Should obese women's access to assisted fertility treatment be limited? A scientific and ethical analysis. Aust N Z J Obstet Gynaecol.. 2017; 57:(5)569-574 https://doi.org/10.1111/ajo.12600

Vujkovic M, de Vries JH, Lindemans J The preconception Mediterranean dietary pattern in couples undergoing in vitro fertilization/intracytoplasmic sperm injection treatment increases the chance of pregnancy. Fertil Steril.. 2010; 94:(6)2096-2101 https://doi.org/10.1016/j.fertnstert.2009.12.079

Wang Y, Ashokan K Physical exercise: an overview of benefits from psychological level to genetics and beyond. Front Physiol.. 2021; 12 https://doi.org/10.3389/fphys.2021.731858

Warburton DER, Bredin SSD Health benefits of physical activity. Curr Opin Cardiol.. 2017; 32:(5)541-556 https://doi.org/10.1097/HCO.0000000000000437

Weber MF, Sarich PEA, Vaneckova P Cancer incidence and cancer death in relation to tobacco smoking in a population-based Australian cohort study. Int J Cancer.. 2021; 149:(5)1076-1088 https://doi.org/10.1002/ijc.33685

Willis SK, Wise LA, Wesselink AK Glycemic load, dietary fiber, and added sugar and fecundability in 2 preconception cohorts. Am J Clin Nutr.. 2020; 112:(1)27-38 https://doi.org/10.1093/ajcn/nqz312

Wise LA, Wesselink AK, Mikkelsen EM Dairy intake and fecundability in 2 preconception cohort studies. Am J Clin Nutr.. 2017; 105:(1)100-110 https://doi.org/10.3945/ajcn.116.138404

Wise LA, Wesselink AK, Tucker KL Dietary fat intake and fecundability in 2 preconception cohort studies. Am J Epidemiol.. 2018; 187:(1)60-74 https://doi.org/10.1093/aje/kwx204

Wright TE, Schuetter R, Tellei J, Sauvage L Methamphetamines and pregnancy outcomes. J Addict Med.. 2015; 9:(2)111-117 https://doi.org/10.1097/ADM.0000000000000101

Xie F, You Y, Guan C, Gu Y, Yao F, Xu J Association between physical activity and infertility: a comprehensive systematic review and meta-analysis. J Transl Med.. 2022; 20:(1) https://doi.org/10.1186/s12967-022-03426-3

Zhou H, Zhang D, Luo Z Association between body mass index and reproductive outcome in women with polycystic ovary syndrome receiving IVF/ICSI-ET. BioMed Res Int.. 2020; 2020:1-7 https://doi.org/10.1155/2020/6434080

Zhu D, Chung HF, Pandeya N Relationships between intensity, duration, cumulative dose, and timing of smoking with age at menopause: a pooled analysis of individual data from 17 observational studies. PLoS Med.. 2018; 15:(11) https://doi.org/10.1371/journal.pmed.1002704

Beyond body mass index: a synthesis of lifestyle factors that may influence in vitro fertilisation outcomes

02 August 2023
Volume 31 · Issue 8

Abstract

There are several lifestyle factors that are thought to potentially impact in vitro fertilisation outcomes, including body mass index, smoking, alcohol consumption, caffeine, dietary patterns and physical activity. Eligibility criteria for in vitro fertilisation in England often require individuals to be non-smokers, drug free and have a body mass index <30kg/m2. Some researchers have questioned the scientific and ethical basis for the use of body mass index thresholds in fertility treatment, citing evidence that other factors may have a greater effect on the chance of success of in vitro fertilisation. This article aims to briefly synthesise the current evidence on how other factors such as smoking, alcohol, recreational drugs, smoking, caffeine, dietary patterns and physical activity may impact in vitro fertilisation outcomes.

Body mass index is used globally to determine access to fertility treatment, including in vitro fertilisation, with different countries imposing diverse limits (De Wert et al, 2014; Tremellen and Savulescu, 2016; Koning et al, 2017). Guidance in the UK imposes an in vitro fertilisation body mass index threshold of 30 kg/m2, with those with obesity advised to lose weight in order to restore ovulation, increase their response to ovulation induction agents and improve pregnancy outcomes (Emokpae and Brown, 2021; NHS, 2022a, b; 2023). A systematic review suggested that women with a body mass index >30 kg/m2 (classified as obese) have a clinical and statistically significant decreased probability of live birth following in vitro fertilisation, compared with women of healthy weight (body mass index: 18.5—24.9 kg/m2) (Sermondade et al, 2019). However, some researchers have questioned the scientific and ethical basis for the use of body mass index thresholds in fertility treatment (Koning et al, 2017; Tremellen et al, 2017), citing evidence that other factors may have a greater effect on the chance of success (Sneed et al, 2008; Koning et al, 2017).

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